Manchester United will face Jose Mourinho’s Internazionale in the last 16 of the Champions League following the draw in Nyon.
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It is one of three Premier League versus Serie A clashes with Arsenal facing Roma and Claudio Ranieri returning to Chelsea with his Juventus side.
Five-time champions Liverpool also face a daunting task as they meet Real Madrid, now under the stewardship of former Tottenham manager Juande Ramos.
Draw in full:
Villarreal v Panathinaikos
Sporting v Bayern Munich
Atletico Madrid v Porto
Olympique Lyon v Barcelona
Real Madrid v Liverpool
Arsenal v AS Roma
Inter Milan v Manchester United
* First legs to be played on February 24 and 25.
* Second legs to be played on March 10 and 11.